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Meta studies are always very interesting and not always super accurate. You are 100% right to shed light on this. One of the things that I've noticed in my research on serotonin is that elevated levels of it can cause health problems. The evidence is pretty clear that high levels of serotonin have a role in cancer.

https://mattcook.substack.com/p/happy-to-horrified-the-lies-of-serotonin

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Yes, scientific studies are often less than perfect. They aren't the end all be all some take them to be.

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